I-Heparin sodium CAS 9041-08-1

Inkcazelo emfutshane:

Igama lomchiza:Heparin lithium

Elinye igama:Ityuwa ye-sodium ye-Heparin

Inombolo yeCAS:9041-08-1

Ibakala:Isitofu/Isihloko/Ekrwada

Inkcazo:EP/USP/BP/CP/IP

Iinkcazelo ngeMichiza:I-sodium ye-Heparin imhlophe okanye i-off-white powder, i-odorless, i-hygroscopic, i-soluble emanzini, i-soluble in organic solvents efana ne-ethanol kunye ne-acetone.Inomrhumo onamandla ongalunganga kwisisombululo se-aqueous kwaye inokudibanisa kunye nezinye ii-cations ukwenza ii-molecular complexes.Izisombululo ezinamanzi zizinzile ngakumbi kwi-pH 7. Inoluhlu olubanzi lokusetyenziswa kweyeza.Isetyenziselwa ukunyanga i-acute myocardial infarction kunye ne-pathogenic hepatitis.Ingasetyenziselwa ngokudibanisa ne-ribonucleic acid ukwandisa ukusebenza kwe-hepatitis B. Xa idibene ne-chemotherapy, kunenzuzo ukukhusela i-thrombosis.Inokunciphisa i-lipids yegazi kunye nokuphucula ukusebenza komzimba womntu.nayo inendima.

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Isicelo

I-sodium ye-Heparin yi-anticoagulant drug, eyi-mucopolysaccharide substance.Yityuwa yesodium yeglucosamine sulfate ekhutshwe kwi-intestinal mucosa yeehagu, iinkomo kunye neegusha.phakathi.I-sodium ye-Heparin inemisebenzi yokuthintela ukuhlanganiswa kweplatelet kunye nokutshatyalaliswa, inqanda ukuguqulwa kwe-fibrinogen kwi-fibrin monomer, inqanda ukubunjwa kwe-thromboplastin kunye nokuchasana ne-thromboplastin eyenziwe, ukuthintela ukuguqulwa kweprothrombin kwi-thrombin kunye ne-antithrombin.

I-sodium ye-Heparin inokulibazisa okanye ithintele i-coagulation yegazi zombini kwi-vitro nakwi-vivo.Indlela yokusebenza kwayo inzima kakhulu kwaye ichaphazela amakhonkco amaninzi kwinkqubo yokudibanisa.Imisebenzi yayo yile: ①Inqanda ukwakheka kunye nomsebenzi wethromboplastin, ngaloo ndlela inqanda iprothrombin ekubeni yithrombin;②Ekugxininiseni okuphezulu, kunokuthintela i-thrombin kunye nezinye izinto zokudibanisa, ukuthintela i-fibrinogen ekubeni yi-fibrin Protein;③ inokuthintela ukudityaniswa kunye nokutshatyalaliswa kweeplatelet.Ukongezelela, i-anticoagulant effect ye-sodium heparin isahambelana ne-sulfate ehlanjululwe kakubi kwi-molecule yayo.Izinto ze-alkaline ezichajiwe kakuhle ezifana neprotamine okanye i-toluidine eluhlaza okwesibhakabhaka inokunciphisa intlawulo yayo embi, ngoko inokuthintela i-anticoagulant yayo.ukujija.Ngenxa yokuba i-heparin inokusebenza kwaye ikhulule i-lipoprotein lipase emzimbeni, i-hydrolyze triglyceride kunye ne-low-density lipoprotein kwi-chylomicrons, ngoko ke inefuthe le-hypolipidemic.

I-sodium ye-Heparin ingasetyenziselwa ukunyanga isifo esibuhlungu se-thromboembolic, i-disseminated intravascular coagulation (DIC).Kwiminyaka yakutshanje, i-heparin ifunyenwe inefuthe lokususa i-lipids yegazi.Isitofu se-Intravenous okanye i-intramuscular injection enzulu (okanye i-injection subcutaneous), i-5,000 ukuya kwiiyunithi ze-10,000 ngexesha ngalinye.I-Heparin sodium ayinayo ityhefu encinci kwaye ukuthambekela ukopha okuzenzekelayo ngowona mngcipheko ubalulekileyo we-heparin overdose.Ayisebenzi ngomlomo, kufuneka ilawulwe ngesitofu.Inaliti ye-Intramuscular okanye i-subcutaneous injection iyacaphuka ngakumbi, ngamanye amaxesha ukuphazamiseka kuyenzeka, kwaye ukugqithisa ngokweqile kunokubangela ukubanjwa kwentliziyo;ngamanye amaxesha ukulahleka kweenwele kunye norhudo.Ukongeza, isenokubangela ukwaphuka okuzenzekelayo.Ukusetyenziswa kwexesha elide kunokubangela i-thrombosis, enokuthi ibe ngumphumo we-anticoagulase-III yokunciphisa.I-sodium ye-Heparin inqatshelwe kwizigulane ezinokuthambekela ukopha, isibindi esinzima kunye nokungasebenzi kakuhle kwezintso, uxinzelelo lwegazi olunzima, i-hemophilia, i-intracranial hemorrhage, isilonda se-peptic, abafazi abakhulelweyo kunye ne-postpartum, i-visceral tumors, i-trauma kunye nokuhlinzwa.